When I hear IT people use the term hybrid, I recall my background and education in biology.  In the biology community, hybrid usually refers to the result from a combination of two different species or subspecies.  For example, a zonkey is a cross between a zebra and a donkey.  More recently, hybrids have also been associated with the controversial practice of genetically modified crops where genes from completely different organisms are spliced into a plant to provide an otherwise unavailable benefit.  Some strains of corn have had a gene added to improve their resistance to popular herbicides.